A miniature fluorescence microscope that weighs less while offering high resolution compared to existing devices will have a range of applications in systems biology. Existing miniature fluorescence microscopes are a standard technique in life sciences, but they only offer two-dimensional (2-D) information. In a new report now on Nature Light: Science & Applications, Kyrollos Yanny, Nick Antipa and a team of scientists in the Joint Graduate Program in Bioengineering, Electrical Engineering and Computer Sciences at the University of California, Berkeley and the Universite libre de Bruxelles Belgium, developed a single-shot 3-D fluorescence microscope. They engineered the new device known as the Miniscope3D by replacing the tube lens of a conventional 2-D miniscope with an optimized multifocal phase mask at the objective's aperture stop. Using the device, Yanny and Antipa et al. optically recorded neural activity in free-moving animals and in long-term in situ imaging applications in incubators and within lab-on-a-chip devices.
from General Physics News - Science News, Physics News, Physics, Material Sciences, Science https://ift.tt/3lLLHNV
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